Is it okay to combine an SSRI (fluoxetine, etc) with an SNRI (Effexor, Cymbalta, or Savella)

July 2011

Is it okay to combine an SSRI (fluoxetine, etc) with an SNRI (Effexor, Cymbalta, or Savella)?

These are sometimes combined to try to improve the antidepressant effect...or to treat multiple conditions.

For example, a patient may end up on an SSRI for depression plus an SNRI for fibromyalgia or pain.

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Table of Contents

Dyslipidemia Lots of patients are asking if they should stop taking niacin (Niaspan, etc) for dyslipidemia
Diabetes confusing the news about Avandia and Actos
Diabetes how to manage diabetes during fasting
Antidepressants Viibryd (VI-brid) marketed as a new "dual-acting" serotonergic antidepressant
Antidepressants Is it okay to combine an SSRI (fluoxetine, etc) with an SNRI (Effexor, Cymbalta, or Savella)
Respiratory & Allergy Singulair is "as good as" inhaled corticosteroids or long-acting beta-agonists for asthma
Respiratory & Allergy Daliresp (DA-li-resp), a new oral tablet for severe COPD in patients with chronic bronchitis
Diarrhea the new oral drug Dificid (fidaxomicin) for Clostridium difficile diarrhea
Restless Legs Horizant for restless legs syndrome
Thyroid Disorders Many older adults get too much levothyroxine (Synthroid, etc)
Infectious Diseases We're running out of antibiotics for multidrug-resistant gram-negative "superbugs"
Statins stronger dosing limits for simvastatin
Hepatitis C two new protease inhibitors for hepatitis C, Victrelis (vic-TREL-is) and Incivek (in-SEE-veck)