new warnings not to combine tamoxifen with certain SSRIs

July 2009

You'll see new warnings not to combine tamoxifen with certain SSRIs...paroxetine, fluoxetine, and sertraline.

Tamoxifen is converted to an active metabolite by CYP2D6 enzymes in the liver.

This conversion can be reduced by drugs that inhibit CYP2D6...and in women who are genetically slow metabolizers of CYP2D6 drugs.

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