proton pump inhibitors (PPIs) might DECREASE the efficacy of clopidogrel (Plavix)

April 2009

There's growing concern that proton pump inhibitors (PPIs) might DECREASE the efficacy of clopidogrel (Plavix).

At first many experts dismissed this because it was based on in vitro platelet aggregation studies...not clinical outcomes.

Now some new published and unpublished studies suggest that patients taking clopidogrel plus a PPI actually have more cardiovascular events.

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